Modalert

Modafinil was first developed in France in the late 1970s as a derivative of Adrafinil. Adrafinil and a number of other sulfinyl benzhydryl compounds were first discovered in 1974. Extensive research on Adrafinil led to it eventually being proposed for the treatment of narcolepsy sleep disorder, first in France during the year 1986. You can buy modalert 200 mg online.

During a test to determine Adrafinil’s mechanism (s) of action, Modafinil was discovered. It has been found that Adrafinil is broken down in the body into the active compound Modafinil, and the inactive modafinilic acid.

After additional research and development, it was possible to synthesize Modafinil directly. Although the two have very similar activities, Modafinil is now used much more widely than its parent drug Adrafinil because it is much more powerful and fast acting.

Like Adrafinil before it, Modafinil was first tested in humans for narcolepsy. Narcolepsy is a sleep-wake disorder that causes excessive daytime sleepiness, potentially poor night sleep, and difficulty staying awake during the day.Some people accidentally fall asleep several times a day.

In several double-blind, placebo-controlled studies, it has been seen that, compared to placebo, Modafinil is significantly better at improving wakefulness and reducing daytime sleepiness in patients with narcolepsy. Modafinil was approved by the FDA in the United States for the treatment of narcolepsy in 1998.

In a similar vein, Modafinil has been extensively researched for other sleep disorders that have excessive sleepiness issues, in particular shift work sleep disorder and obstructive sleep apnea / hypopnea syndrome ..

Shift Work Sleep Disorder is a disorder that can occur when normal circadian rhythms (daily sleep / wake cycles with day and night) are disrupted due to late night and night work shifts. People with this disorder often experience excessive sleepiness when they wake up (usually late at night and stay overnight) and sometimes experience insomnia when they try to sleep (usually during the daytime).

Because Modafinil is a renowned wakefulness-promoting drug (eugeroic agent), studies have been conducted using it to improve wakefulness in people with shift work sleep disorder. The study found that compared to a placebo, Modafinil, taken one hour before work shift, improved performance on the psychomotor vigilance test, in the form of fewer and fewer focus dips.

Obstructive sleep apnea / hypopnea syndrome. (OSAHS) This is a medical condition that causes impairment or complete cessation of breathing during sleep. The muscles that hold the tongue and soft palate in place can involuntarily relax, causing blockages in the airways. Sleep hypopnea refers to the blockage of partial contractility and shallow, shortness of breath, while sleep apnea refers to the cessation of breathing due to a blockage of a full airway.